When should I choose an alpha-2 agonist over a stimulant?

Both alpha-2 agonists reduce prefrontal cortex "noise" through the same receptor mechanism, but a 10-fold difference in receptor selectivity produces meaningfully different clinical profiles - guan...

Which alpha-2 agonist is better for ADHD with tics?

Both alpha-2 agonists reduce prefrontal cortex "noise" through the same receptor mechanism, but a 10-fold difference in receptor selectivity produces meaningfully different clinical profiles - guan...

Which is better for ADHD with sleep problems?

Both alpha-2 agonists reduce prefrontal cortex "noise" through the same receptor mechanism, but a 10-fold difference in receptor selectivity produces meaningfully different clinical profiles - guan...

What's the preschool efficacy and tolerability data for alpha-2 agonists?

Both alpha-2 agonists reduce prefrontal cortex "noise" through the same receptor mechanism, but a 10-fold difference in receptor selectivity produces meaningfully different clinical profiles - guan...

Pharmacology

How Do Guanfacine and Clonidine Compare for Treating ADHD?

Questions this summary answers

How do guanfacine and clonidine compare for treating ADHD?
When should I choose an alpha-2 agonist over a stimulant?
Which alpha-2 agonist is better for ADHD with tics?
Which is better for ADHD with sleep problems?
What's the preschool efficacy and tolerability data for alpha-2 agonists?

Go Deeper

This summary distills key findings. For the full clinical discussion with complete citations, explore the source lessons.

Primary source

Non-Stimulant MedicationsAlpha-2 Agonists: Guanfacine & Clonidine

Also covered in

ADHD Across the LifespanPreschool ADHD Comorbidity IADHD + SUD & Tic Disorders Comorbidity IIADHD + Sleep Disorders: The 24-Hour Disorder

Last updated: 2026-04-12

PsychHQ

How Do Guanfacine and Clonidine Compare for Treating ADHD?